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Players choose the side they want to represent in a fantasy battle between infectious disease, the Lords of Pestilence, and treatments, the Apothecary Healers. Each Apothecary champion has a unique set of gifts and abilities that specialize in battling certain diseases. The Lords of Pestilence have specific symptoms or drug resistances that must be considered as the Apothecary Healers design their battle strategy.
The cards each have an artistic interpretation of the characters as villains, creatures or vixens. They are used with the backdrop of a fantasy world depicted on two play mats. The teams battle using real-world understanding of microbiology and common medical therapies for infectious disease to determine if the antibiotics are used properly to fight off the infectious diseases, or if the diseases will be victorious. Also included are 30 special events cards, which include spells and real-life adverse effects that influence the battle.